| 引用本文： |
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朱大元,蒋山好,姜远英,贺祥,李医明,曾华武.玄参提取物的抗炎和抗氧活性[J].第二军医大学学报,1999,20(9): [点击复制]
- 朱大元,蒋山好,姜远英,贺祥,李医明,曾华武.Antiinflammatory and antioxidant effects of the extracts from Scrophularia ningpoensis Hemsl[J].Acad J Sec Mil Med Univ,1999,20(9): [点击复制]
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| 摘要: |
| 目的：研究玄参提取液和玄参中4种单体成分的抗炎和抗氧活性。方法：应用(l)角叉菜胶及眼镜蛇毒致大鼠脚趾肿胀实验；(2)Fe2+／半胱氨酸诱导肝微粒体脂质过氧化；(3)AAPH诱导红细胞氧化性溶血实验，观察玄参提取液以及玄参中环烯醚萜甙类成分哈帕酯甙、哈帕甙和苯丙素甙类成分安格洛甙C、阿格托甙的作用。结果：玄参提取液具有较好的抗肿胀作用。在相应剂量，其苯丙素甙类成分具有较强的抗氧活性，环烯醚萜甙类成分作用较弱。结论：玄参的抗炎、抗氧化作用可能主要与其苯丙素甙类成分有关。 |
| 关键词: 玄参 抗炎药 抗氧化药 |
| DOI： |
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| Antiinflammatory and antioxidant effects of the extracts from Scrophularia ningpoensis Hemsl |
| 朱大元,蒋山好,姜远英,贺祥,李医明,曾华武 |
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| Abstract: |
| Objective： To evaluate the antiinflammatory and antioxidant effects of the extracts of Scrophularia ningpoensis Hemsl. (SN) in vivo and in vitro. Methods: (1) Carrageenan and cobra venom induced rat paw edema； (2) Fe2+/cystine induced rat liver microsomal lipid peroxidation and (3) 2,2′-azobis(2-amidinopropane) dihydrochloride (AAPH) induced oxidative hemolysis were used to study the effects of the extracts from SN. Results: The crude extract of SN had more potent antiinflammatory effect in vivo. At a dose corresponding to the quantity contained in the crude extracts, the phenylpropanoid glycosides had potent antioxidant effects, while the iridoid glycosides of SN had lower antioxidant activities. Conclusion: The antiinflammatory activity of SN appears to have some relationship with the antioxidant effect of phenylpropanoid glycosides. |
| Key words: Scrophularia ningpoensis Hemsl. antioxidants |
