| 引用本文： |
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邓本强,侯晓军,张仁琴,菝??丁素菊.中性粘多糖对沙土鼠脑缺血再灌注红细胞膜的保护作用[J].第二军医大学学报,1999,20(9): [点击复制]
- 邓本强,侯晓军,张仁琴,菝??丁素菊.Protective effect of neutral mucopolysaccharide on RBC membrane during ischemia reperfusion brain damage in gerbil[J].Acad J Sec Mil Med Univ,1999,20(9): [点击复制]
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| 摘要: |
| 目的：探讨中性粘多糖(NM)对沙土鼠缺血再灌注后红细胞膜的保护作用。方法：采用沙土鼠脑缺血再灌注模型，观察NM对红细胞免疫粘附功能的影响，检测红细胞超氧化物歧化酶(RBC-SOD)和脂质过氧化物代谢产物丙二醛(RBC-MDA)的含量，同时与淀粉对照组进行比较。结果：NM可使沙土鼠再灌注时RBC免疫粘附功能得到恢复；RBC-SOD的含量轻度提高；RBC-MDA含量明显降低。结论：NM通过抗氧化作用对RBC免疫粘附功能有调节作用，从而对沙土鼠缺血再灌注脑组织损伤时红细胞膜起到保护作用。 |
| 关键词: 中性粘多糖 缺血再灌注 免疫 红细胞 脂质过氧化 |
| DOI： |
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| Protective effect of neutral mucopolysaccharide on RBC membrane during ischemia reperfusion brain damage in gerbil |
| 邓本强,侯晓军,张仁琴,菝??丁素菊 |
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| Abstract: |
| Objective： To study the protective effect of neutral mucopolysaccharide (NM) on RBC membrane during ischemia reperfusion brain damage in gerbil. Methods: The functional changes of red blood cell immune adherence (RCIA) and the content of red blood cell superoxidate dismustase (RBC-SOD), red blood cell malonialdehyde (RBC-MDA) were observed by means of cerebral ischemia reperfusion in gerbil. Results: NM recovered the function of RCIA; increased RBC-SOD; decreased RBC-MDA. Conclusion: NM regulates the function of RCIA by antioxygenic effection, and has the protective effect on RBC membrane during ischemia reperfusion brain damage. |
| Key words: neutral mucopolysacchande cerebral ischemic reperfusion immunity erythrocytes lipid peroxidation |
