Objective:：To investigate the therapeutic effects of somatostatin(SS) and oxymatrine(Oxy) on experimental pancreatitis and their mechanisms. Methods: Acute experimental pancreatitis rats were induced with supramaximal dosage of caerulein injected subcutaneously. The treatment group administered with SS intravenously and Oxy i.p.,and related parameters were examined. Results: Compared with acute pancreatitis group, pancreatic mass, edema, inflammatory cell infiltration and serum amylase were significantly reduced in SS or Oxy treatment group.Besides,the inflammatory cytokines in serum or pancreatic tissue were both significantly decreased(P<0.01). Conclusion:SS and Oxy have beneficial effects on treatment of experimental acute pancreatitis. The mechanism maybe related to inhibiting the releasing and activity of inflammatory cytokines