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  • 沈茜,章同华,丁继军.黄芪皂甙对小鼠柯萨奇B3病毒性心肌炎的治疗作用[J].第二军医大学学报,1999,20(9):    [点击复制]
  • 沈茜,章同华,丁继军.The effect of astragalus saponins on mice viral myocarditis caused by CVB3[J].Acad J Sec Mil Med Univ,1999,20(9):   [点击复制]
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黄芪皂甙对小鼠柯萨奇B3病毒性心肌炎的治疗作用
沈茜,章同华,丁继军
0
()
摘要:
目的:探讨黄芪皂甙对BALB/c小鼠柯萨奇B3(CVB3)病毒性心肌炎的治疗作用。方法:雄性BALB/c小鼠腹腔接种CVB3,制成急性病毒性心肌炎模型,接种1 h后腹腔内注入黄芪皂甙5.64×10-3 mg/g,1次/d ×7 d,观测小鼠存活率、血浆乳酸脱氢酶(LDH)和谷草转氨酶(GOT)、体温、心肌病理变化和心肌病毒滴度的影响。结果:黄芪皂甙治疗组比病毒感染组存活率明显增高,血浆LDH和GOT明显降低,体温保持正常,心脏质量/体质量值显著降低,心肌病理变化减轻,心肌匀浆病毒滴度降低(P<0.05)。结论:黄芪皂甙有治疗病毒性心肌炎的作用。
关键词:  黄芪皂甙、柯萨奇病毒B组  病毒性心肌炎
DOI:
基金项目:
The effect of astragalus saponins on mice viral myocarditis caused by CVB3
沈茜,章同华,丁继军
()
Abstract:
Objective: To investigate the effect of astragalus saponins on mice myocarditis caused by CVB3. Methods: Male BALB/c mice was inoculated i.p. with 1000 TCID50 CVB3 and administered 5.64× 10-3 mg/g astragalus saponins i.p. for 7d starting 1 h after viral inoculation. The survial rate,the body temperature, LDH and GOT,the heart histopathologic changes,the virus titer of heart were observed. Results: The survival rate was higher, LDH and GOT release was lower, the body temperature was higher and similar to normal mice, the virus titer of heart was lower, the heart mass/body mass ratio was lower, the histopathologic changes (necrosis, degeneration and cellular infiltration) was lighter in astragalus saponins treated group than in viral control group. The statistic is valuelar. Conclusion: Astragalus saponins has therapeutic effects on viral myocarditis. The machenism may be anti-viral, improving of circulation and lightening of myocardial injury
Key words:  astragalus saponins  coxsackie B viruses  viral myocarditis