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  • 朱泉芳,刘延玲,郝家骅,张宝仁,朱家麟,赵仙先.血管内皮生长因子在动脉粥样硬化斑块中的表达[J].第二军医大学学报,1999,20(9):    [点击复制]
  • 朱泉芳,刘延玲,郝家骅,张宝仁,朱家麟,赵仙先.The expression of vascular endothelial growth factor in atherosclerotic plaques[J].Acad J Sec Mil Med Univ,1999,20(9):   [点击复制]
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血管内皮生长因子在动脉粥样硬化斑块中的表达
朱泉芳,刘延玲,郝家骅,张宝仁,朱家麟,赵仙先
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()
摘要:
目的:观察血管内皮生长因子(VEGF)在动脉粥样硬化斑块中的表达。方法: 利用高胆固醇饲料复制兔动脉粥样硬化模型,采用免疫组织化学方法,观察VEGF在胸主动脉粥样硬化斑块中的表达。结果:正常兔主动脉组织中未见VEGF蛋白阳性表达,而动脉粥样硬化斑块区VEGF蛋白表达明显增加。结论:动脉粥样硬化斑块中VEGF表达增加,并可能参与动脉粥样硬化发生和发展的病理过程。
关键词:  血管内皮生长因子  动脉粥样硬化
DOI:
基金项目:
The expression of vascular endothelial growth factor in atherosclerotic plaques
朱泉芳,刘延玲,郝家骅,张宝仁,朱家麟,赵仙先
()
Abstract:
Objective:To investigate the expression of vascular endothelial growth factor (VEGF) in atherosclerotic plaques.Methods: The rabbit atherosclerotic model was developed by high cholesterol feeding.The VEGF protein level in atherosclerotic plaques were studied by means of immunohistochemistry.Results:VEGF protein was not detected in normal rabbit aortic arteries,the increased production of VEGF protein were found in atherosclerotic plaques.Conclusion:VEGF protein have a high level expression in atherosclerotic plaques and may involve the pathogenesis and progression of atherosclerosis.
Key words:  vascular endothelial growth factor  atherosclerosis