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  • 徐冠南,吕随峰,吴剑英,李先兴,丁国善,马优钢,肖飞,付志仁.来氟米特对大鼠不同器官移植排斥反应的抑制作用[J].第二军医大学学报,1999,20(9):    [点击复制]
  • 徐冠南,吕随峰,吴剑英,李先兴,丁国善,马优钢,肖飞,付志仁.The inhibitory effects of leflunomide on transplantation rejection of different solid organs in rats[J].Acad J Sec Mil Med Univ,1999,20(9):   [点击复制]
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来氟米特对大鼠不同器官移植排斥反应的抑制作用
徐冠南,吕随峰,吴剑英,李先兴,丁国善,马优钢,肖飞,付志仁
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摘要:
目的:验证来氟米特(leflunomide)对同种异体急性排斥反应的抑制作用。方法:60只成年Lewis雄性大鼠作为受体,ACI大鼠作为供体,分别行原位肝脏、小肠、肾脏以及异位心脏、胰腺移植。除对照组外,给予每只受体来氟米特5 mg.kg-1.d-1治疗14 d。结果:与对照组比较,来氟米特可显著延长受体及移植物存活时间。其中,来氟米特可将2/6肾移植受体及5/5肝移植受体存活时间延长至100 d以上。结论:来氟米特可显著延缓大鼠同种异体小肠、心脏及胰腺器官移植排斥反应;可有效控制肝脏及肾脏移植排斥反应。
关键词:  来氟米特  器官移植  排斥反应
DOI:
基金项目:
The inhibitory effects of leflunomide on transplantation rejection of different solid organs in rats
徐冠南,吕随峰,吴剑英,李先兴,丁国善,马优钢,肖飞,付志仁
()
Abstract:
Objective:To investigate the immunosuppressive effects of leflunomide(Lef) in various organ transplantation models in rats. Methods: Sixty male Lewis rats received othortopic liver, small bowel, kidney and heterotopic heart, pancreas transplantation from ACI rats. Lef in its powder form was suspended in 1%carboxymethylcellulose and was administered at 5 mg.kg-1.d-1 by gavage for 14 d. Results: The survival time of rats in Lef group is significantly longer than the corresponding untreated control group.Besides, 2/6 rats with kidney transplantation and 5/5 rats with liver transplantation were alive over 100 d. Conclusion: Lef as monotherapy in short term treatment can delay acute rejection in heart, pancreas and small bowel transplantation, and lead to long term functional graft survival in kidney and liver transplantation in strong rejecting rat combination. In view of the effect of organ preference by Lef, this agent may be of special benefit to clinical kidney and liver transplantation.
Key words:  leflunomide  organ transplantation  rejection