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  • 施靖华,王元和,陈腾,赵荣华.大肠癌患者癌细胞DNA含量及倍体分布与某些胃肠激素水平的关系[J].第二军医大学学报,1999,20(9):    [点击复制]
  • 施靖华,王元和,陈腾,赵荣华.Analysis of the relation between cancer cell DNA and changes of gastrin and somatostatin in patients with colorectal cancer[J].Acad J Sec Mil Med Univ,1999,20(9):   [点击复制]
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大肠癌患者癌细胞DNA含量及倍体分布与某些胃肠激素水平的关系
施靖华,王元和,陈腾,赵荣华
0
()
摘要:
目的:探讨大肠癌患者癌细胞DNA含量、倍体分布与体内胃泌素(G)、生长抑素(SS)水平变化,以及肿瘤临床病理参数之间的关系。方法:以图像分析法测定40例大肠癌患者癌细胞DNA含量及二倍体偏离指数(2cDI);放免法测定血清G,血浆、肿瘤、癌近旁粘膜和癌远旁粘膜的SS水平;借助计算机以多因素逐步回归法分析癌细胞DNA含量、2cDI、上述胃肠激素水平与肿瘤临床病理特点之间的关系。结果:肿瘤SS上升伴随着DNA含量和2cDI显著下降(P<0.01);癌近旁粘膜SS与DNA含量(P<0.05)和2cDI(P<0.01)呈显著正相关;直肠癌细胞DNA含量和2cDI明显增高(P<0.01)。结论:内源性SS参与了对癌细胞DNA合成的调节;提高肿瘤和癌近旁粘膜SS水平将有助于抑制大肠癌细胞内DNA的合成。
关键词:  大肠肿瘤  脱氧核糖核酸  逐步回归分析
DOI:
基金项目:
Analysis of the relation between cancer cell DNA and changes of gastrin and somatostatin in patients with colorectal cancer
施靖华,王元和,陈腾,赵荣华
()
Abstract:
Objective: To evaluate the relation between DNA contents, 2c deviation indexes(2cDI) of colorectal cancer cells,changes of some gastrointestinal hormones levels,and the cancer clinical pathologic features. Methods: In 40 patients with colorectal cancer, DNA contents, 2cDI of the tumor cells (determined by automatical imaging cytometry), serum gastrin, plasma somatostatin(SS),tumor SS, cancer-adjacent mucosa SS and cancer-distant mucosa SS levels (assayed by RIA), and the cancer clinical pathologic features were analyzed by multiple variable stepwise regression with a computer. Results: The increases of tumor SS closely accompanied by the decrease of the cancer cell DNA contents or 2cDI (P<0.01). Cancer-adjacent mucosa SS had a significant positive correlation to the cancer cell DNA contents or 2cDIs (P<0.05 and P<0.01, respectively). The cancer cell DNA contents and 2cDIs increased significantly in patients with rectal cancer (P<0.01). Conclusion: The endogenous SS may play an important role in the regulation of DNA synthesis in cancer cell, elevating the tumor SS level and keeping the cancer-adjacent mucosa SS at high level, thus inhibiting the DNA sythesis in colorectal cancer cell.
Key words:  colorectal neoplasms  DNA  stepwise regression analysis