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  • 黄勤,邹大进,赵庆.糖尿病患者血清晚期糖化终产物含量测定及临床意义[J].第二军医大学学报,1999,20(9):    [点击复制]
  • 黄勤,邹大进,赵庆.The concentration of serum AGE and its clinical significance in diabetic patients[J].Acad J Sec Mil Med Univ,1999,20(9):   [点击复制]
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糖尿病患者血清晚期糖化终产物含量测定及临床意义
黄勤,邹大进,赵庆
0
()
摘要:
目的:探讨2型糖尿病患者血清晚期糖化终产物(AGE)浓度。方法:采用ELISA法检测2型糖尿病患者及正常人血清AGE含量。结果:15例无糖尿病慢性并发症和11例有糖尿病慢性并发症的患者血清AGE/蛋白分别为0.597±0.540和0.750±0.390,均显著高于正常人(P<0.01)。结论:糖尿病患者血清AGE水平较正常人明显上升;血清AGE水平可以作为糖尿病血糖控制和糖尿病慢性并发症监测的参考指标。
关键词:  糖化终产物  糖尿病
DOI:
基金项目:
The concentration of serum AGE and its clinical significance in diabetic patients
黄勤,邹大进,赵庆
()
Abstract:
Objective:To evaluate the relationship between serum AGE and diabetic chronic complication (DCC). Methods: Serum AGE in diabetic patients was measured by competitive ELISA. Results: Both of 15 diabetic patients with DCC and 11 diabetic patients without DCC had higher mean serum AGE concentrations than that of normal group (P<0.01). Conclusion: This may be the increasing production of endogenous AGE that the diabetic group had a higher mean serum AGE than normal group,serum AGE may provide an indicators of long term blood glucose control and predict the occurances of diabetic chronic complications.
Key words:  glycation end products  diabetes mellitus