Objective：To investigate the expression of recombined human immunoglobulin X light chain 022 and TOM1 gene and to determine the protein expression of HSIGVL022 in omental adipose tissues of patients with type 2 diabetes and insulin resistance（T2DM-IR）. Methods： Fat tissues from greater omentum of T2DM-IR patients and normal controls were obtained. The mRNA levels of recombined human immunoglobulin λ light chain 022 and TOM1 were measured by fluorescent quantitative RTPCR;expression of HSIGVL022 protein was identified by immunohistochemistry. Results： The mRNA levels of HSIGVL022 and TOM1 in T2DM-IR patients were （34 140±6 160） copy/million house-keeping genes and （4 440±617） copy/million housekeeping genes, respectively; those in control group were （5 930-661） copy/million house-keeping genes and （1 360±82） cop- y/million house-keeping genes,respectively. There were significant difference between the 2 groups （P〈0. 05）. The mRNA level of HSIGVL022 was significantly higher than that of TOMI（P〈0.01） and was linearly correlated with homeostatic model assessment-insulin resistance（HOMA-IR） index（P〈0.05）. The positive rates of HSIGVL022 protein in T2DM-IR and control group were （12.43±2.41） % and （2.31±0.48） %, respectively; the strong positive rates were （6.62! 1.69）% and （2.12±0.34）%, respectively（P〈0.05）. Conclusion： Both HSIGVL022 and TOM1 are expressed in the fat tissues of greater omenturn,with the level of HSIGVL022 higher than that of TOM1. The 2 genes are up-regulated in patients with insulin resistance and the HSIGVL022 protein increases correspondingly. The mRNA level of HSIGVL022 is linearly correlated with HOMA-IR index. The 2 genes are possibly related with insulin resistance in type 2 diabetes