Hepatic ischemia-reperfusion injury (IRI) is a critical problem of liver surgery,especially when comes to liver transplantation.Presently,there are no effective measures for diagnosis,prevention and therapy of IRI,as the mechanisms of IRI still remain unclear.This review summarizes several new hepatic ischemia-reperfusion markers related to cell signal transduction pathway,including transcription factor STAT，HIF-1 and PPARs,transmission factor MAPK， membrane receptor TLR4 and PARs,and iNOS.Animal studies have indicated that IRI was ameliorated by activating or blockading these markers, which might serve as targets for diagnosis,prevention and therapy of IRI.