Objective:To optimize the support relationship between units for military medical material supply and the supported units,so as to promote the rational utilization and allocation of units for military medical material supply in a region.Methods: The methods of Delphi and integer programming of operation research were adopted to construct optimal model based on the basic principles of joint logistics support.Results: Optimal distribution models were established based on the primary channel supply and fixed units position.The model was used to optimize the medical support relation in a certain region.Conclusion: The application of the optimal model suggests that the model is feasible.Decision support system developed based on the optimal model combined with geographic information system provide theoretical evidence and information tool for the adjustment of medical material support relation in a region.