Objective： To compare the effects of electret and chemical enhancers in enhancing the transdermal delivery of meloxicam. Methods： The study was divided into 4 groups, including meloxicam patch group （control）, chemical enhancer ＋ meloxicam patch group,electret meloxicam patch,and electret ＋ chemical enhancer ＋ meloxicam patch group. The in vitro skin permeation of meloxicam from patches was examined by using a modified Franz diffusion cell. Ultraviolet spectrophotometry （362 nm） was used to analyze the drug concentration in the receptor. The 10 h-cumulated permeation amount of meloxicam from patchs was calculated in 3 experimental groups and were compared with that the control group. The enhancing abilities of electret and chemical enhancers were compared and the synergistic effect of them was assessed. Results： （1） 1 %. 3 % and 5 azones showed 1.20,1.33 ,and 1.26 fold-increases in the 10 h cumulated permeation of meloxiam respectively as compared with control group（P〈0.05）. （2） Most of the chemical enhancers used in thisstudy（1%,3% and 5%azones,10% ethyloleate,1% menthnol,and 300% sulphoxiade） ,except for 20 % propylene glycol,had enhancing effect on transdermal delivery of melocicam. Ethyl oleate（10%） was proven to be the most potent enhancer, showing a 1.86 fold cumulated permeation that of the control group（P〈0. 05） ; （3） Electret was more potent than the chemical enhanrers in promoting meloxieam transdermal delivery, showing a 2. 16-fold cumulated permeation that of control group（P〈0. 05）;（4） Electret improved the enhancing effect of chemical enhancers in this study. The cumulated permeation of meloxicam in electret ＋ chemical enhancer ＋ meloxicam patch group was 1.14-2.82 folds that of the chemical enhancer ＋ meloxicam patch group（P〈0. 05）. Conclusion： Electret has a good promoting effect for transdermal drug delivery and can be used as a novel enhancer in transdermal delivery of drugs