Apoptotic mechanism of Pathogenic fungi has become a focus of study due to the worsening situation of clinical drug resistance in fungi.Apoptosis of Pathogenic fungi is a complicated network involving many pathways,regulators and effectors.Besides,it is closely related to the autophagy,mitochondrial apoptotic pathways,and changes of endogenous and exogenous factors.As a new target of antifungal agent,apoptotic pathways are of great clinical importance.This paper reviews the apoptotic pathways of Pathogenic fungi.