As a tropical infectious disease,the dengue fever is now one of the most important arthropod-borne diseases from a medical and public health perspective.Antibody-dependent enhancement of dengue virus infection and the unclear pathogenesis mechanism hamper the prevention and treatment of the disease.No efficient preventative and therapeutic drugs are available now,but much progress has been made in the last few years in the drug prevention and therapy of dengue fever.To better understand the current situation,this article reviews the recent advances in the development of anti-dengue vaccines,small-molecule drugs,monoclonal antibodies and the relevant problems.