Glioma is a common tumor of the central nervous system.Tumor cells and tumor microvascular endothelial cells play a very important role in the development and progression of gliomas.Nogo protein is a kind of inhibitory protein in myelin sheaths of the central nervous system and an inhibitor of axonal regeneration in the central nervous system.This paper reviews the relationship between glioma cells and glioma microvascular endothelial cells.