Objective:To observe the efficacy and safety of the multi-functional self-controlled pressure hemostatic bandage(MSPHB) in treatment of canine femoral artery bleeding,so as to lay a foundation for clinical application.Methods:Rubber tubing,half-hitch tourniquet and our MSPHB were used to treat 18 anesthetized mongrel dogs with fatal femoral artery injury. The pressure under the tourniquet and the related physiopathological parameters were measured 0.5,1,3,and 6 h after tourniquet application. The injuries of the involved tissues were observed.Results:The 3 treatments all had prominent hemostasis effect and the arterial incisions had no bleeding after treatment in all groups. The pressure produced by MSPHB was significantly lower than those by the other two tourniquets (P<0.05). The changes of serum CK,K+ and skin temperature in MSPHB group were significantly smaller than those of the other 2 groups at all defined time points (P<0.05). Also,PvO2 and SvO2 in the MSPHB group were significantly higher than those of the other 2 groups (P<0.05),but the PvCO2 was significantly lower than those in the other 2 groups(P<0.05).The injury of the muscle in the MSPHB group was slighter than those of the other 2 groups 6 h after application of tourniquets. Conclusion:MSPHB has similar hemostasis effect to rubber tubing and half-hitch tourniquet,and it also has less injury to the involved tissues.