Objective:To analyze the multi-mode ultrasound manifestation of male breast cancer,and to discuss its value in clinical diagnosis and differential diagnosis.Methods: The clinical data of 15 male patients with pathologically-confirmed breast cancer were retrospectively reviewed.All the patients were examined by multi-mode ultrasound (including 2D,3D,color Doppler flow imaging \[CDFI\],and intravenous contrast-enhanced ultrasound \[CEUS\]).The ultrasonic characteristics of the 8 patients were compared with those of 7 patients with hyperplasia.The diagnostic values of the ultrasonic characteristics were summarized.Results: (1) 2D sonogram:6 of 7 cases with ultrasonically diffused masses,which were all initially interpreted as hyperplasia on ultrasound,were confirmed pathologically,with an accurate rate of 86%.All the 8 patients had unilateral focal masses (ipsilateral in 3 of 8).They were all diagnosed as having breast cancer by ultrasound,with hypoechoes and irregular shape.Three of them had micro-calcification.All the 8 patients were confirmed to have breast cancer pathologically,with the accurate rate of ultrasound being 100%.(2) CDFI and CEUS:hyperplasia patients had weak blood flow signal and breast cancer patients all had rich blood flow signal.High frequency CEUS showed that only 3 breast cancer patients had marked micro-vascular enhancement,while low-frequency CEUS showed prominent enhancement in all cancer cases.(3) 3D reconstruction:coronary display of 2 focal masses showed “convergent sign”.Conclusion: Multi-mode ultrasound imaging can provide comprehensive information of male patients with breast disorders; it may facilitate the early detection,early diagnosis and early treatment for male breast cancer.