Objective:To study the antifungal activity of triazole alcohols by introducing N-butyl and substituted benzyl as side chain.Methods: Fourteen title compounds were synthesized and characterized by 1H NMR,IR,and LC-MS．The MICs of the compounds were determined by in vitro test using 8 clinical pathogenic fungi．Results: The title compounds exhibited potent antifungal activities against nearly all fungi tested(except for Aspergillus fumigatus),especially for the deep infection ones.Compounds 6a,6d, and 6j showed a 16-fold activity(with a MIC80 value of 0.015 6 μg/ml) as that of fluconazole against Microsporum gypseum.Compounds 6m and 6n showed a 128-fold activity(with a MIC80 value of 0.003 9 μg/ml) as that of fluconazole against Candida albicans,and their activities were higher than those of other positive controls.Conclusion: The title compounds with N-butyl and substituted benzyl all have antifungal activities.