Objective:To evaluate the application of ureteroscope-assisited laparoscopic varicocelectomy with two trocars only.Methods: We retrospectively analyzed the clinical efficacy and safety of ureteroscope-assisited laparoscopic varicocelectomy with only two trocars in management of 11 patients with grade Ⅱ-Ⅲ varicocele,who were treated in our hospital between Jun.2008 to Jun.2009 and were followed up for 3-15 months.Results: The operation was successful in all the 11 cases.The mean operation time was (19.4±1.1)min(ranging 16-28 min).There were no complications after the procedure; the patients were allowed for ambulation on the next day after operation and were discharged on the third day.The sperm count was(2 609±208)×104/ml three months after operation,which was significantly higher than that before operation(1 463±128) ×104/ml(P<0.01).There was no recurrence or testis atrophy.Conclusion: Ureteroscope-assisited laparoscopic varicocelectomy with only two trocars is safe,effective,and easy-to-perform,and it has less complications and trauma.