ERCP has become an important method for diagnosis and treatment of digestive diseases, but the high incidences of post-ERCP complications (PEP), especially for post-ERCP pancreatitis, have limited its application. Prevention of PEP has become a focus of ERCP-related studies.Current drug prevention of PEP is not satisfactory, and there has not been a single drug which can effectively prevent PEP. In contrast, non-pharmacologic preventive techniques such as pancreatic stent placing and guide wire cannulation have been proven to have prominent effects in preventing PEP, which brings new hopes for PEP prevention. This paper reviews the studies on non-pharmacologic prevention of PEP.