GATA3 transcription factor plays an important role in the growth and differentiation of normal breast tissues, and it is also closely related to the tumorigenesis of breast cancer.The roles of GATA3 vary in different breast cancer subtypes.This paper reviews the relationship of GATA3 with normal breast tissue and the tumorigenesis of breast cancer, in an attempt to provide theoretical evidences for future clinical applications of GATA3 in breast cancer.