\[Abstract\]ObjectiveTo summarize our experience on application of magnetoencephalography (MEG) and awaking anesthesia in microsurgical treatment of dysembryoplastic neuroepithelial tumors in the functional areas.MethodsThe range of the functional area was largely defined by MEG; intraoperative cortical electrical stimulation was used under awaking anesthesia to identify the border of function area and dysembryoplastic neuroepithelial tumors. Dysembryoplastic neuroepithelial tumors were resected under microscope in four patients and the outcomes of the patients were observed.ResultsSatisfactory outcomes were obtained in the 4 patients and there were no injuries in the function area. No epileptic seizures or recurrence of dysembryoplastic neuroepithelial tumors were found during long term follow-up.ConclusionCombined treatment using MEG and awaking anesthesia contributes to safe and effective surgical treatment of dysembroplastic neuroepithelial tumors in the function areas.