Rudolf Virchow described the links between inflammation and cancer in the 19th century. Recently more progress has been made in the area, including versicanTLR2TNFα pathway and RANKLRANKIKKαMaspin pathway, which casts great new lights on cancer therapy.The traditional therapies solely targeting tumor cells is becoming increasingly limited, and drugs aiming at the tumor microenvironment are gradually gaining popularity, especially those aiming at inflammation cells, which participate in the metastasis and are closely related to the tumorigenesis and progression of tumor. This article reviews the recent progress on the links between inflammation and tumor metastasis.