Abstract: Objective To compare the effect between the postmenopausal women with osteoporosis who take both vitamin E and calcium carbonate D3 tablets and take calcium carbonate D3 tablets only. Methods Select 145 postmenopausal women with osteoporosis who are aged from 51 to 70. Devide these women randomly into the test group (the group of take both vitamin E and calcium carbonate D3 tablets and the control group ，the group of take calcium carbonate D3 tablets only. Women in the test group is 74. Women in the control group is 71. Women in the test group take a pill of Carbonate D3 tablets and a pill of vitamin E everyday; while women in the control group take a pill of calcium carbonate D3 tablets everyday. The two group women are all requied to take drags for one year . Then compare the situation of the clinical symptoms ，the changes of bone gla-protein（BGP），the bone mineral density (BMD)，the estradiol and the serum alkaline phosphatase （AKP）of the women between the two group . Results The improvement of the clinical symptoms 、 the bone mineral density (BMD)，bone glo-protein（BGP），estradiol，alkaline phosphatase （AKP） in the test group is better than the control group (P<0.05). Conclusion The curative effect of the conbine-using Vitamin E and calcium carbonate D3 tablets in postmenopausal women with Osteoporosis is better than using calcium carbonate D3 tablets only.