ObjectiveTo construct, verify and optimize an interactive three-dimensional(3-D) digital anatomic model of human brain, so as to pave a way for accurate display of the cerebral tissues and for guiding clinical practice. MethodsA series of 176 sections(T1WI)of a healthy male volunteer, who aged 24 years old and underwent 1.5 T General Electric Signa MRI examination, were used as the original data, which were pretreated using commercially available software (Mimics 8.0, Z-brush, Imageware, Photoshop and Maya 8.5). The rough model was established and was adjusted. After verification, the model was subjected to 3-D painting and rendering. ResultsThe 3-D model of human brain was successfully constructed based on the 176 original images. The outline calculated according to the model corresponded well with the edge of the original MRI image. After painting and rendering, the 3-D model showed a satisfactory display efficacy. The model could be viewed from any angle and could be rotated 360 degrees in any plane. Moreover, it could be rotated, reduced and enlarged using the zoom function, allow viewing from different directions. ConclusionWe have successfully constructed a 3-D model of the human brain and some adjacent organs with high accuracy and satisfactory displays efficacy, which lays a foundation for guiding future clinical practice.