Long non-coding RNA (lncRNA) is considered to be longer than 200 nucleotides with little or no protein-coding capacity. LncRNAs regulate gene expression at Epigenetic level, transcription as well as post-transcription level, and they are involved in various physiological and pathological processes in organisms. However, very few lncRNAs has been demonstrated. Furthermore, the functions and mechanism of lncRNA are still unclear. In this review, we mainly discussed the recent study progress of LncRNA and its roles in clinical diseases.