[ABSTRACT] Objective:To assess the clinical effect of Multimodal Antiemetic Therapy on Postoperative Nausea and Vomiting in Patients Undergone Gynecological Laparoscopic Surgery. Methods:Ninety gynecologic patients scheduled for laparoscopic Surgery were randomly divided into three groups with 30 cases each. Group A (Multimodal Group) received multimodal antiemetic therapy including the management of using TIVA with propofol for induction and maintenance of anesthesia，avoidance of volatile anesthetics，minimization of opioids，combination of using antiemetics ondansetron 4mg + dexamethasone 2.5mg + droperidol 1.25mg for preventing PONV.Group B （Combination Group）received combination antiemetics therapy. Group C（Control Group）didn’t receive special interventions for PONV. Patient demographics,risk profiling,incidence of PONV and patient total satisfaction were observed and compared.Result: The preoperative expected risks of PONV in three groups were high. Group A and B were more effective than Group C in preventing PONV.Compared with Group B, Group A has a higher complete response rate and greater patient satisfaction. Conclusion：In Patients Undergone Gynecological Laparoscopic Surgery,evaluated to have a high risks of PONV preoperatively, multimodal antiemetic therapy has an effective prevention, also associated with a better clinical effect and greater patient satisfaction when compared with combination antiemetics therapy.