Objective：To analyze the expressions of EMMPRIN and MMP-7 in human endometrial cancer,and to evaluate the clinical significance of these two markers in the progression of endometrial cancer．Methods: The expressions of EMMPRIN and MMP-7 was examined by immunohistochemistry in all specimens,and the results were statistically analyzed．Results：The positive rates of EMMPRIN and MMP-7 in normal endometrium 、atypical hyperplasia and endometrial carcinoma were 9.09％ and 6.82％（4/44 and 3/44）、43.1% and 41.2%（22/51and 21/51）、61％ and 59.8％（50/82 and 49/82）,respectively,with significant differences found between the latter two groups(P<0.05). EMMPRIN and MMP-7 expressions in endometrial cancer was not correlated with the size of primary tumor or patient ages，ang it was correlated with histological grades and lymphatic metastasis(P<0.05). Spearman rank correlation test analysis showed that the expressions of EMMPRIN and MMP-7 in endometrial cancer was positively correlated with them (r = 0.863, P <0.01). Conclusion：EMMPRIN and MMP-7 may participate in the development ,progression,metastasis of endometrial cancer, may be synergistic in endometrial cancer of the lymph node metastases．