Objective: To study the antifungal activity of triazole alcohols by introduction of n-butyl and triazole as side chain. Methods: sixteen 1-(1H-1, 2, 4-Triazole-1-yl)-2-(2, 4-Difluorophenyl)-3-Substituted-2-Propanol were synthesized and characterized by 1H NMR and LC-MS．The MICs of the compounds were determined by in vitro test in eight human pathogenic fungi．Results: The title compounds exhibited potent antifungal activities against nearly all fungi tested. Conclusion: The title compounds with n-butyl and triazole side chain have antifungal activities.