[Abstract] 0bjective To investigate the preparation method of dispersible tablets of isoflavonoids from Rhizoma belamcandae. Methods The formula of isoflavonoid dispersible tablets was optimized by orthogonal experiment with disintegrating time as index and influential factors were observed. According to the optimum prescription we made three batch samples and had quality evaluation such as disintegration time, dissolution rate et. Results The optimized formula was A2B2C2. The contents of crospovidone, gelling starch and gum arabic were 12%，14 %and 3% respectively. As crospovidone and gelling starch，the ratios of before granulation to after pre-compress all were 2:1. The products formulated with the optimum techniques which disintegrated in 30s and dissolved in 45mins met the quality specification of dispersed tablet. Conclusion The dispersible tablets showed good distribution homogeneity and higher dissolution rate. The preparation process is simpler，feasible，and adapt to industrial production.