Objective To investigate the effectiveness of systemic moist therapy in treating stage Ⅱ-Ⅳ pressure ulcers. Methods From January 2010 to January 2011, 21 males and 9 females with pressure ulcers,with an age range of 60-80 years and a mean of 71±8.5 years old, were treated with systemic moist dressing changes. Seven cases had Ⅱ degree pressure ulcers, 12 had Ⅲ degree and 11 had Ⅳ degree. Wound granulation and wound healing were observed after systemic moist treatment. Results The wounds were full of flesh granulation and the infection was controlled after the moist dressing therapy; all the wounds were healed within 1-6 weeks. A followed up of 3 months found no recurrence. Conclusion Moist therapy is a satisfactory method to treat deep pressure ulcers, and it is worth popularizing.