【Abstract】Objective To report short-term follow-up on 8 patients with obliterative urethral stricture treated with the antegrade—retrograde via flexible cystoscopy urethrotomy with a cold knife． Methods From September 2007 to April 2010， 8 cases of obliterative urethral stricture underwent antegrade-retrograde via flexible cystoscopy endoscopic urethrotomy with a cold knife．The obliterative stricture was 0．8 to 2．0cm．Results The strictures of all patients were non－passable when using conventional retrograde urethrotomy．The antegrade—retrograde via flexible cystoscopy urethrotomy with a cold knife were successful in all cases.Mean operation time were 20 mins.Urethral catheter (F20-F22)was left in situ for 4-6 weeks．All patients were followed for 6-24 months (mean 1 8 months)．During the follow—up of 8 patients,3 patients had no stricture recurrence．Further intermittent urethral dilations(6-16 procedures) for 4 cases and second endoscopic urethrotomy for 1 case as stricture recurred 3 months after first treatment were mandated．Conclusions The antegrade—retrograde urethrotomy via flexible cystoscopy with a cold knife could be a viable and effective option for gaining access across strictures when traditional methods fail．Although all patients could be spared open surgery on first stage treatment，the long-term successful rate of this technique remains to be evaluated