Objective To investigate the association of depression with glycosylated hemoglobin, lipid metabolism and coping style in patients with type 2 diabetes mellitus (DM). Methods A total of 73 patients with type 2 DM were divided into depression group (n=31) and non-depression group (n=42) according to the Results of Zung Self-Rating Depression Scale. The anxiety statuses were evaluated by Zung Self-Rating Anxiety Scale(SAS). The coping style was assessed by Medical Coping Modes Questionnaire (MCMQ). Moreover, the blood HbA1c, triglycerides (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C) were also compared between the two groups. Results The SAS standard score and MCMQ score of resignation in the depression group were significantly higher than those in the non-depression group (P<0.01). The MCMQ score of confronce and avoidance, blood HbA1c, TG, TC, HDL-C, and LDL-C were not significantly different between the 2 groups. Conclusion It is suggested that type 2 DM patients with resignation coping style are more liable to have depression.