ObjectiveTo explore the treatment effect of Shengmai injection on patients with chronic heart failure combined with coronary heart disease. MethodsFrom 2009 to 2011, 56 patients with coronary heart disease combined with chronic heart failure were equally divided into two groups randomly. Patients in the control group received conventional treatment and the observation group was also given Shengmai injection (40 ml Shengmai injection in 250 ml glucose, once daily for 7 days). The following parameters were examined and compared before and one week after treatment: left ventricular ejection fraction (LVEF), left ventricular end-systolic diameter (LVESD),left ventricular end-diastolic diameter (LVEDD),stroke volume (SV) and left ventricular fractional shortening (FS). ResultsAll the above five parameters were significantly improved after treatment in both groups (P<0.05), and the improvement in the observation group was significantly greater than that in the control group (P<0.01). The total effective rate in the observation group was 82.1%, which was significantly higher than that in the control group (75.0%， P<0.05). No obvious adverse reaction was noticed in the two groups. ConclusionShengmai injection can definitely improve the systolic function of heart in patients with heart failure.