ObjectiveTo investigate the effect of family interaction on depression and anxiety in secondary vocational school students. MethodsA total of 95 students in a secondary vocational school in Shanghai were investigated by Family Assessment Device (FAD), Questionnaire of Systemic Family Dynamics (QSFD), Center for Epidemiologic Studies Depression Scale(CES-D), State-Tand Anxiety Inuentory (STAI) and Adolescent Life Events Questionnaire (ALEQ). Pearson correlation and hierarchical multiple linear regression were employed to analyze the data collected. ResultsFamily interaction and adolescent life events were both significantly correlated with depression and anxiety in the subjects (P<0.05). When the impact of adolescent life events was controlled, hierarchical regression analysis showed that affective intervention (β=0.417, P<0.01), affective reaction (β=0.275, P<0.05) and problem solving (β=0.223, P<0.05) were correlated with depression; affective reaction (β=0.414, P<0.05) was correlated with state anxiety; and affective reaction (β=0.333, P<0.01) and disease conception (β=-0.239, P<0.05) were correlated with trait anxiety. ConclusionIt is suggested that family interaction is correlated with depression and anxiety in secondary vocational school students, and family interaction may play an important role in mental health of secondary vocational school students.