ObjectiveTo study the association of alleles and genotype frequencies of rs4402960 in insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) gene with type 2 diabetes mellitus (T2DM) in Han population of Inner Mongolia region. MethodsAllele-specific polymerase chain reaction was used to genotype the rs4402960 polymorphism of IGF2BP2 in 360 Han population living in the Inner Mongolia region, including 166 patients with T2DM (T2DM group) and 194 normal controls (NC group). ResultsThe frequencies of T allele, TT and GT genotype of rs4402960 in T2DM group were 41.6%,12.1% and 59.0%, respectively, which were significantly higher than those in the NC group (10.6%,3.6% and 13.9%, all P<0.05). The GG genotype frequency was 28.9% in T2DM group, being significantly lower than that in the NC group (82.5%, P<0.05). Carrying T allele was a risk factor of T2DM (OR=6.02, 95%CI=4.075-8.895). ConclusionT allele of rs4402960 polymorphism in IGF2BP2 gene might be a risk factor of T2DM, and G/T polymorphism is associated with T2DM. IGF2BP2 rs4402960 might be a susceptible gene of T2DM in Han population living in Inner Mongolia region.