ObjectiveTo explore the value of liver acquisition with volume acceleration (LAVA) multi-phase dynamic enhanced technique combined with magnetic resonance diffusion weighted imaging(ＤＷＩ) in evaluating prostate lesions. MethodsTotally 67 prostate disease patients confirmed by histopathology and follow-up were included in the present study. The patients included 19 with prostate cancer (PCa) and 48 with benign prostate hyperplasia (BPH). LAVA multi-temporal enhancement and DWI scanning were performed, and the values of apparent diffusion coefficient (ADC) were calculated. Two experienced radiologists evaluated the results in a double-blinded manner; the qualitative diagnosis accuracy rates of the T-SI curves alone or in combination with ADC for PCa and BPH were compared. ResultsThe accuracy rates of T-SI curve alone for qualitative diagnosis of PCa, BPH were 57.9% and 72.8%, and those of T-SI curve combined with ADC value were 73.7% and 87.5%, respectively. ConclusionLAVA multi-phase dynamic enhanced technique combined with ADC is of great value for differential diagnosis of benign and malignant prostate lesions.