Liver transplantation (LT) has become an important treatment for end stage hepatobiliary disorders. However, biliary complications following LT are common and greatly hamper the clinical efficacy. Endoscopic therapy has been the first-line modality for these biliary problems, though technically difficult and complex. We have managed more than 1 000 cases of complications following LT via endoscopic approach. Here we summarized the therapeutic methods and strategies of our center, hoping to provide evidence for better clinical practice.