Objective To investigate clinical features of 237 gastric cancer patients from plateau region in Tibet. Methods Clinical information of 237 patients with gastric cancer admitted to hospitals in the Tibet region was retrospectively analyzed. Clinical features including sex, age, clinical, endoscopic and histopathologic compositions were statistically compared. Results In all patients, the sex ratio of male to female was 3.2:1; 51.5% were aged from 40 to 59 years; 60.8% were peasants or cadres; 68.4% had tumors in gastric antrum; 82.3% had infiltrated type of gastric cancer; 81.0% presented with lowly-differentiated adenocarcinoma; the positive rate of CEA (carcino-embryonic antigen, as a tumor marker) was 30.0%; 95.2% had stages III to IV cancer evaluated based upon TNM criterion (tumor, node, metastasis). Conclusion In the Tibetan plateau, gastric cancer was commonly seen in gastric antrum of middle-aged or senior men. The severity of carcinoma was high. Effective and comprehensive measures should be actively adopted to prevent and treat gastric cancer in the plateau region according to local clinical features.