Objective: To explore the effects of DanHong on Spontaneously Hypertensive Rats (SHR) fed by high-fat diet. Methods: 1.Six weeks old SHR were divided into three groups: normal diet group， high fat diet group， DanHong and high fat diet group. Each group had eight SHR. Twenty-four SHR had been treated for 12 weeks. 2.The tail blood pressure and the body weight were detected every two weeks. 3. At the end of the study， the rats were fasting for 12hrs and the blood samples were taken to detect the fasting blood glucose and lipids levels. The endothelium-dependent and the endothelium-independent relaxation of the aorta were detected by wire myograph. Results: 1. DanHong could prevent the increase of the body weight， fasting blood glucose and lipids on SHR fed by high-fat diet， P<0.01 or P<0.05. 2. DanHong could improve the endothelium-dependent relaxation of the aorta artery on SHR fed by high-fat diet， P<0.05. 3.DanHong could decrease the tail blood pressure of SHR fed by high-fat diet，P<0.05. Conclusion: DanHong could improve the metabolic disorder of SHR fed by high-fat diet，ameliorate the endothelium-dependent relaxation of the aorta artery， and decrease the tail blood pressure.