Proteoglycan-induced arthritis model in mice: research progress
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Department of Joint And Bone Disease,Changhai Hospital,Second Military Medical University,Department of Joint And Bone Disease,Changhai Hospital,Second Military Medical University,Department of Joint And Bone Disease,Changhai Hospital,Second Military Medical University

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    Abstract:

    Proteoglycan-induced arthritis (PGIA) is a unique systemic autoimmune disease model of spondyloarthritis (SpA) induced by intraperitoneal immunization of either BALB/c or certain C3H colonies with cartilage proteoglycan. This model is currently the only systemic autoimmune mice model with axial skeleton manifestation, which has become a focus of study in SpA modeling. Here in this review we summarize the methods of animal model building, phenotype identification, immunological characteristics and pathways involved in bone remodeling of PGIA based on previous studies, hoping to provide references for study on SpA animal model.

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History
  • Received:September 03,2014
  • Revised:March 18,2015
  • Adopted:April 17,2015
  • Online: May 19,2015
  • Published:
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