Atrial fibrillation (AF) is one of the most common types of arrhythmia in clinical practice. AF is prone to be permanent or even permanent AF from paroxysmal AF, which was called AF self-stabilization. Atrial electrical remodeling (AER) is a typical change of atrial electrophysiology in the AF self-stabilization process. Small conductance Ca²⁺-activated K⁺ channel (SK channel) is recently found and widely distributed in cardiac myocytes, and it is highly sensitive to Ca²⁺. Researches have shown that SK channels may affect AF self-stabilization through influencing the process of AER directly. This review aimed at summarizing the mechanisms of SK channels in the AF self-stabilization progress and the related intervention measures and discussing the role of SK channels in clinical practice.