Influence of microRNAs on cardiomyocyte viability in myocardial infarction and its therapeutic potential: research progress
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Department of Cardiovascular Surgery,Dalian Children’s Hospital,Dalian Medical University,Da’lian,Liaoning Province,Department of Cardiovascular Surgery,Dalian Children’s Hospital,Dalian Medical University,Da’lian,Liaoning Province,Department of Cardiovascular Surgery,Dalian Children’s Hospital,Dalian Medical University,Da’lian,Liaoning Province,Department of Cardiovascular Surgery,Dalian Children’s Hospital,Dalian Medical University,Da’lian,Liaoning Province,Department of Cardiovascular Surgery,Dalian Children’s Hospital,Dalian Medical University,Da’lian,Liaoning Province,Department of Biomedical Engineering,Fourth Military Medical University,Xi’an,Shaanxi Province,Department of Biomedical Engineering,Fourth Military Medical University,Xi’an,Shaanxi Province,Department of Cardiovascular Surgery,Dalian Children’s Hospital,Dalian Medical University,Da’lian,Liaoning Province

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Supported by National Natural Science Foundation of China (81102687) and the Excellent Doctoral Project of the Fourth Military Medical University (2013D01).

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    Abstract:

    MicroRNAs (miRs), initially discovered in eukaryotes, are endogenous small noncoding RNAs that regulate gene expression. Myocardial infarction is a common cardiovascular event resulting in cardiac remodeling and subsequent chronic heart failure. A number of miRs have been reported to regulate important pathophysiological processes of myocardial infarction. They have multiple effects on the survival and proliferation of cardiomyocytes, which is of great significance to myocardial infarction and other ischemic heart diseases. In this review we introduced the general knowledge of myocardial infarction and miRs, and described several miRs which are crucial for survival and proliferation of cardiomyocytes. We also discussed the therapeutic potential and limitations of miRs in future treatment of myocardial infarction.

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History
  • Received:September 04,2015
  • Revised:April 13,2016
  • Adopted:August 26,2016
  • Online: August 26,2016
  • Published:
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