Objective To analyze the clinical characteristics of the death cases of Ebola virus disease (EVD), so as to provide control and treatment reference for EVD. Methods and Results The second medical team of PLA to Liberia arrived in Liberia at the beginning of 2015 and stayed for two months. Totally we treated 5 confirmed EVD cases and 2 of them died. Case 1 was a young female patient; she had clinical manifestations of febrile, fatigue, anorexia, diarrhea and hemorrhage. She died soon after admission and was confirmed positive of Ebola virus (EOV) by swab sample. Case 2 was an old male patient who was presented to China Ebola Treatment Unit with symptoms of febrile, fatigue, muscular soreness, anorexia and severe diarrhea; and his viral load in blood remained high during the course of illness. Both patients died from hypovolemic shock. Conclusion Tracing and isolating the contacts, early diagnosis and treatment, and providing basic health care services for the infected are the cores for prevention of Ebola virus disease.