Role of cell autophagy in treatment of Alzheimer's disease

doi:10.16781/j.0258-879x.2016.01.0077

Home > Archive>Volume 37, Issue 1, 2016 >77-82. DOI:10.16781/j.0258-879x.2016.01.0077

Role of cell autophagy in treatment of Alzheimer's disease
DOI:
                        10.16781/j.0258-879x.2016.01.0077
                    
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Affiliation:Department of medicine,Changhai Hospital,Second Military Medical University,The outpatient department,Gansu provincial Military Command,Team of pharmacy,School of pharmacy,Second Military Medical University,Department of medicine,Changhai Hospital,Second Military Medical University,Department of medicine,Changhai Hospital,Second Military Medical University,Department of medicine,Changhai Hospital,Second Military Medical University,Department of medicine,Changhai Hospital,Second Military Medical University
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Fund Project:Supported by National Natural Science Foundation of China (81402819, 81373327), Natural Science Foundation of Shanghai (13ZR1408500) and Program of Health Department of PLA General Logistics Department (14ZJ202-3).

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Abstract:

Objective Alzheimer's disease(AD)is a brain neural degenerative disease characterized by progressive cognitive and memory impairment. The pathogenesis of Alzheimer's disease remains unclear and there has been no effective treatment up to now. Autophagy plays an important role in clearing abnormally accumulated proteins and damaged organelles and in maintaining intracellular homeostasis and cell metabolism. This paper reviewed the role of autophagy in treatment of Alzheimer's disease, hoping to provide reference for discovering new treatment target for Alzheimer's disease.

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Received:April 10,2015
Revised:May 31,2015
Adopted:September 07,2015
Online: January 22,2016
Published:

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