Helicobacter pylori is a microaerophilic bacterium which parasitizes in the digestive tract and is closely related to the occurrence of various gastrointestinal diseases, such as chronic gastritis, gastric ulcers and so on. Recently, studies have shown that majority of patients with liver disease also suffer from Helicobacter pylori infection, but the correlation between them and the specific mechanism remain unclear. Through reviewing the related literatures, this review summarized the relationship between Helicobacter pylori and the development and progression of liver diseases, such as chronic hepatitis, fatty liver, liver cancer and hepatic encephalopathy, etc.