Activation and regulation of NLRP3 inflammasome: research progress

doi:10.16781/j.0258-879x.2016.07.0868

Home > Archive>Volume 37, Issue 7, 2016 >868-872. DOI:10.16781/j.0258-879x.2016.07.0868

Activation and regulation of NLRP3 inflammasome: research progress
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                        10.16781/j.0258-879x.2016.07.0868
                    
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Affiliation:Department of Health Toxicology,College of Tropical Medicine and Public Health,Second Military Medical University,Department of Health Toxicology,College of Tropical Medicine and Public Health,Second Military Medical University,Department of Health Toxicology,College of Tropical Medicine and Public Health,Second Military Medical University,Department of Health Toxicology,College of Tropical Medicine and Public Health,Second Military Medical University,Department of Health Toxicology,College of Tropical Medicine and Public Health,Second Military Medical University,Department of Health Toxicology,College of Tropical Medicine and Public Health,Second Military Medical University,Department of Health Toxicology,College of Tropical Medicine and Public Health,Second Military Medical University
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Fund Project:Supported by Major Program of National Science and Technology (2014ZX09J14106-06C, 13CXZ005), National Natural Science Foundation of China (81473291, 81402651, 81402654), and Natural Science Foundation of Shanghai (13ZR144940).

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Abstract:

Inflammasome is a vital part of innate immunity, and NLRP3 inflammasome is by far the most thoroughly studied inflammasome complexes that have been described. NLRP3-activating signals include toxins secreted by pathogens, crystalline molecules and endogenous danger signals. Activation of NLRP3 inflammasome needs two steps:priming and activating. The priming step affects NLRP3 at the transcriptional and posttranscriptional modification levels; the activating step is associated with ion flowing, mitochondria and lysosomes. In this paper we also reviewed the negative regulation of NLRP3 inflammasome at the expression, assembly and activation levels.

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Received:October 15,2015
Revised:February 26,2016
Adopted:April 15,2016
Online: July 27,2016
Published:

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