Lipoma is a common benign tumor composed of mature adipocytes posed,which is mostly in the fat layer. It is the fat tissue nodules and can be found anywhere in the body, but the limbs, trunk is common, followed by retroperitoneal and gastrointestinal wall places. Intraperitoneal and intramuscular lipoma is relatively rare, moreover,the large intra-abdominal and leg muscles simultaneously is even rarer, now we are report a case that a giant lipoma between the abdominal cavity and thigh muscle in the Second Affiliated Hospital of Nanchang University in 2015 .The clinical manifestations , treatment and prognosis of the disease will be summarized in this report.