Hepatocellular carcinoma(HCC)is an aggressive malignancy with a high mortality rate. Prognosis can be improved significantly with early diagnosis. However, current imaging technologies and tumor biomarkers for early diagnosis of HCC are unsatisfied. Emerging evidence shows that tumor cells release substantial amounts of RNAs into the circulation that can not be degraded by ribonucleases and are present at sufficient levels for quantitative analyses.Long non-coding RNAs(lncRNAs) play critical roles in the development of HCC. Some lncRNAs have been reported significantly altered in expression with HCC progression, and they may thus serve as potential diagnostic biomarkers for HCC. This review summarized the recent advance in circulating lncRNAs as diagnosis biomarkers for HCC.