Underwater weapons have been widely used and their applications have become a main characteristic of modern naval battles. It imposes a severe threat to the combatants above or below water surface. The injury mechanism and characteristics of underwater explosion are quite different from those of the land explosion, which has become a research focus of military medicine around the world. In this paper we systematically reviewed the literatures and the current status of biological effect of underwater explosion injury and discussed its future development, hoping to improve our understanding and promote further in-depth studies.